Background: The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma resulting in progressive decline in forced expirat
Implementation of variance reduction techniques applied to the pricing of investment certificates
Certificates are structured financial instruments that aim to provide investors with investment solutions tailored to their needs.Certificates can be modeled using a bond component and a derivative component, typically an options strategy.The pricing of Soap/Handcare certificates is typically performed using the Monte Carlo numerical methodology.Su
Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures
The trigeminal ganglion is implicated in the underlying pathology of migraine and temporomandibular joint disorders (TMD), which are orofacial pain conditions involving peripheral and central sensitization.The neuropeptide calcitonin gene-related peptide (CGRP) is synthesized in some trigeminal ganglion neurons, and its release promotes inflammatio